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  • Lipid composition, physical state, and lipid peroxidation of tumor membranes.

    abstract::Studies were carried out on microsomes isolated from the highly differentiated (slow-growing) Morris hepatoma 9618A, on microsomes and plasma membranes from the poorly differentiated (fast-growing) Morris hepatoma 3924A, and rat liver used as control. The lipid composition (phospholipid and cholesterol content, degree...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338401200404

    authors: Galeotti T,Borrello S,Minotti G,Palombini G,Masotti L,Sartor G,Cavatorta P,Arcioni A,Zannoni C

    更新日期:1984-01-01 00:00:00

  • Control of protein degradation and growth phase in normal and neoplastic cells.

    abstract::Cells have to double their protein mass in order to divide. Whether this is achieved through increased synthesis (PS), decreased degradation (PD), or a combination of both is still debated. Likewise open are other basic questions: whether, beyond differences relating to growth phase (GP) or rate, reduced PD rates are ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338401200312

    authors: Baccino FM,Tessitore L,Bonelli G

    更新日期:1984-01-01 00:00:00

  • Occurrence of myeloid bodies in rats following two-year administration of imipramine hydrochloride.

    abstract::Sprague-Dawley CD rats received daily oral doses (45 mg/kg) of the cationic amphiphilic tricyclic antidepressant imipramine HCl (Tofranil) for up to two years. Representative specimens of liver, lung, spleen, mesenteric lymph node, retina and dorsal root ganglion were examined for myeloid bodies (MB). The extent that ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338301100102

    authors: Spaet RH,Sullivan DJ,Diener RM

    更新日期:1983-01-01 00:00:00

  • Statistical support of the proposed National Toxicology Program protocol.

    abstract::Statistical issues related to the design, analysis and interpretation of carcinogenicity studies are considered. A proposed modification of the "standard" National Cancer Institute (NCI) design of carcinogenicity studies in rodents is discussed. The primary objective was to obtain a design that maintained the power of...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338301100113

    authors: Haseman JK

    更新日期:1983-01-01 00:00:00

  • Non-reversibility of vinyl chloride carcinogenesis in rodents.

    abstract::A review of the data obtained from various studies on carcinogenicity of vinyl chloride (VC) in rodents, particularly on the effect of dose, age, duration of exposure and potential reversibility of lesions, revealed that vinyl chloride-induced carcinogenicity in rodents was dose and time related; no recovery occurred ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338301100210

    authors: Bhandari JC

    更新日期:1983-01-01 00:00:00

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